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pentobarbital will lessen the level or influence of estradiol vaginal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.pentobarbital decreases levels of elvitegravir/cobicistat/emtricitabine/tenofovir DF by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. May possibly cause lack of virologic res